The Eagles, looking for 5-0, are on the road facing the Cardinals. Murray and the Cardinals looked better in Week four, but face MUCH stiffer competition this week. The Cardinals losing 3 starters from their O-line to injury against the league's toughest pass rush is hardly ideal.
The Eagles are better in almost every offensive and defensive category when compared to the Cardinals, and any categories where the Eagles showed weakness (as in Week one points allowed) they have addressed. They have controlled play in their games, are very good in the Red zone on both sides of the ball, and have been adaptable. Facing a tough pass rush last week, the Eagles produced monster yardage with the run game.
The most telling category for me is quarterback pressure. The Eagles, as noted, are first in sacks, and the Cardinals are 32nd. Allowing Hurts and Philadelphia's very fine pass offense that kind of freedom is very dangerous. Against a stout Eagles defense, I don't see Murray or the Arizona run offense having a comfortable game. Philadelphia at 6-0 seems like a distinct possibility. Take the Eagles to win and cover.