Kansas City at Arizona 4:25 ET
Cardinals (+) over Chiefs- Arizona Cardinals head coach Kliff Kingsbury, who recruited Mahomes to Texas Tech. Now, he has to coach against him for the first time in the 2022 season opener when his Cardinals clash with the Chiefs on Sunday. Kingsbury, of course, has watched the development of his own quarterback, Kyler Murray, who enters his fourth season. Cards are not getting much respect after closing 2021-22 they way they did. I expect this one to come down to the final gun...take ARIZONA!