Christian McCaffrey showed his amazing running ability as well as his pass catching out of the backfield, with 187 total yards last game. The Saints can't give him too many touches to him, when he runs wheel routes, he can make 5 yd receptions into a 20 yarder in a blink. New Orleans will be tough as playing a Sean Payton team is never easy, but at home, the Panthers will be fighting. If New Orleans comes in thinking they will roll - they could be in for a brawl. Carolina looked too strong running between the tackles - and Darnold looked able to beat safeties down field, they showed improvement. McCaffrey will be able to make plays with his feet - and then Darnold will get things done that teams don't always pay attention to. The Panthers are 1-0 in the NFC South standings, and any hopes they have of laying claim to the division wonít allow too many setbacks along the way. The Saints are 0-4 ATS in their last 4 games in Week 2. Carolina wins taking the points. PREDICTION: Panthers win 24-21