Memphis is a very good offensive team and they have plenty of weapons to do damage with, especially in the passing game with an experienced signal caller in Seth Henigan. South Florida has struggled defensively this season as they surrender 289.4 yards per game through the air. The Bulls are just 118th in the nation in scoring defense by allowing 32.8 points per game on the year. Memphis is 28th in that department by allowing 18.4 points a contest. Look for Memphis to take advantage of South Florida's defensive issues to come up with the win here.