Kansas City is coming off a Mahomes Interception that sealed the win for the Bills. The 49ers are coming off an embarrassing loss to the Falcons. San Francisco has yet to face a team that is even close to the skill of the Chiefs. The 49ers have lost to Chicago, Denver and Atlanta. I think the 49ers defense will try their best but will be facing a pissed off Mahomes and the Chiefs will win and cover.