The Cardinals are coming into this game off of their 1st win of the season as they beat the Cowboys 28-16 in their last game. The Cardinals have been underestimated all season as they have played well in all 3 of their games and their defense has been a lot better than expected as well. Now that the Cardinals have beaten the Cowboys, teams will not be looking through them as much anymore and that is going to make their games even tougher for them to win now. They are going up against a 49ers team that is definitely not looking through them as they are a division rival and they have also had extra time to prepare for this game after playing last week on Thursday night. The 49ers have one of the best rosters in the NFL on both offense and defense so they are going to dominate the Cardinals here with good defense and their great running game. The Cardinals have already been struggling to move the ball on offense in their games and they are going to struggle even more against one of the best defenses in the league here. They may have caught the Cowboys offguard but the 49ers have an even better defense and they are going to be ready for this game considering how they beat the Cardinals by over 20 points in both games last season. The 49ers not only have a great defense that will hold the Cardinals to very few points, but they also have too many weapons on their offense for this Cardinals defense to defend against. The Cardinals have been playing well in their first 3 games of the season as they have been catching teams by surprise but now that they beat Dallas the surprise is over and this is the perfect spot for them to finally get blown out as they have one of the worst rosters in the league. The 49ers will cover the spread in this game.