The last time Josh Allen went up against Arizona with Kyle Murray leading the team was in 2020 on the road and they lost 32-30 to Arizona. There’s been some changes on both sides since that game and the Bills seem weaker without players like Tra’Davius White, Poyer and Morse, not to mention losing WR’s Stefon Diggs and Gabe Davis. Allen doesn’t have a lot of options to throw to. This Bills team is a much weaker team that will face a rejuvenated Cardinals team that had to play most of its season without Murray, but is back at the helm with improvements on both sides of the ball. This is a good matchup for Arizona and they can go toe to toe against Allen in this one, especially on offense as they can move the ball, and both will get their points on these defenses. Josh Allen has been one of the top QB’s in the league with the most turnovers and interceptions and he hasn’t cleaned that up as it seems to be his achilles heel year after year, especially in big games. On the flip side, this Cardinals team is filled with young talent like Marvin Harrison Jr, and their offensive line is strong, and Kyle Murray has a great covering record when he travels across the country to play in the EST zone. Murray is 11-3 ATS with Arizona versus opponents. Arizona is 8-3 against the spread in non divisional games while Buffalo is 5-5 against the spread at home. Buffalo is 2-6 against the spread in their last 8 games when favorites of 5 or more points.

Best bet: take the points with Arizona.