Four straight meetings between these teams have finished over the total, including September's 27-24 Rams win. LA has scored at least 20 points in seven of their past eight games. During that stretch, they're averaging 25.5 points per game. In their first meeting with San Fran, the Rams managed 27 points without Kupp or Nacua active. On the other side, the 49ers are facing a defense that's 24th in scoring and 28th in yards per play. San Francisco's offense averages the second-most yards per play. Moving the ball won't be an issue for a Niners offense that averages 26.9 points at home. That includes four performances with at least 30 points in seven tries. The over is the play for this game.