I don't want to overreact to these team's opening games. Pittsburgh destroyed Austin Peay while Syracuse got buried in the fourth quarter by North Carolina. 
But I do keep in mind that Austin Peay isn't a Division I team while North Carolina is a top-25 team. 
So Pittsburgh definitely is stepping up in class. I don't trust Pittsburgh coach Pat Narduzzi to cover a big margin because I'm never sold on his offenses and I'm not a fan of Pitt QB Kenny Pickett. The Panthers also have a bad record as home chalk - 8-19 ATS the past 27 times in that role. 
I recall last September when Pittsburgh hosted Delaware. The Panthers were 27 1/2-point favorites. It took a fourth quarter touchdown for the Panthers to eke out a 17-14 victory. 
I expect Syracuse to play a full four quarters, something it didn't against North Carolina. The Orangemen were hanging in through three quarters in that matchup before the game got out of hand.