Take away Nick Bosa, Richard Sherman and assorted other defensive players and what is left for the 49ers? A defense that gave up 43 points at home to the Dolphins last week. 
The Rams' offense is far more potent than Miami's. The Rams have numerous receiving weapons, including two good tight ends, rank fourth in the NFL in total yards and have maybe the league's sharpest play-caller in Sean McVay. Jared Goff is having a big season.  
McVay has been surprisingly conservative at times this season. That shouldn't be the case here facing a banged-up 49ers' secondary and lacking their best pass rusher. 
The 49ers' offense should be far better this week. Jimmy Garoppolo is healthier and got the rust off last Sunday. He also has his weapons back, including San Francisco's No. 1 running back, Raheem Mostert. 
The Rams also have injuries in their secondary. LA ranks third in scoring defense holding foes to only 18 points a game. That number is misleading, though, since the 49ers held Washington and the Giants to a combined 19 points in its last two games. The Rams surrendered 35 points on the road to the Bills three games ago. 
There were 80 and 65 points, respectively, scored in the two meetings last season between the teams with the Rams winning, 41-39, and losing, 34-31.