The Texans are on the upswing following a much needed coaching change going from toxic Bill O'Brien to popular Romeo Crennel. The Texans responded to the move by getting their first victory, rolling past Jacksonville by 16 points last week. 
Houston played the hardest September schedule of any team. But now that portion of the schedule is finished and the Texans have their confidence and morale up. 
The Texans draw Tennessee in a vulnerable spot. The shorthanded Titans are fat and happy after rolling past the Bills, 42-16, this past Tuesday. So this is a very short week for Tennessee, which isn't up to full strength and is dealing with the distraction about its supposed lack of adherence to pandemic protocols. 
The Titans are 4-0, but their first three victories came by a combined six points all stemming from game-winning field goals that occurred with less than two minutes left.  
Tennessee is a more well-rounded team than Houston. But the Texans have the better quarterback and the two best defensive players in J.J. Watt and linebacker Zach Cunningham. 
If the Texans are going to get back into the AFC South Division race they need to win this game. They are the team with the greater urgency.