Patrick Mahomes alone is enough to be confident in the Chiefs beating the Raiders by more than a TD. Mahomes is firmly in the MVP discussion with a 25-to-1 TD-to-interception ratio. Mahomes has accounted for 15 touchdowns in five career games against the Raiders and their defensive coordinator, Paul Guenther. The Raiders are among the bottom-four in sacks, sack ratio and quarterback hit rate. So Mahomes is going to have time to operate. If you throw out a heavy wind game against the Browns, the Raiders have given up more than 30 points per game during their last six games.
But, wait, there is more. 
The Chiefs have monster revenge. The Raiders dealt them their lone loss. Kansas City also is off its bye. No coach is better with an extra week during the regular season than Andy Reid, who is 18-3 in this role. 
The Chiefs' defense has been playing better allowing 17 or fewer points in three of their last four games. 
The Raiders were missing three starting offensive linemen in their last game and their defense is dealing with COVID protocols with seven players affected, including safety Jonathan Abram.