Western Kentucky is the class of Conference USA at 10-2 in league and 17-5 overall. Old Dominion is 10-4 in league, but 14-6 overall. The Monarchs have fattened their record by playing four games against Charlotte and Middle Tennessee State during their last six games. 
Old Dominion is 4-10-1 ATS versus above .500 opponents. I don't see the Monarchs stepping up to keep things close here. Old Dominion can't hit 3-pointers, nor defend well against 3-pointers. Western Kentucky can exploit those perimeter weaknesses while dominating inside with 6-foot-11 star center Charles Bassley, who averages 17.8 points and 11.8 rebounds. 
I see a double-digit Hilltoppers victory.