Stephen Nover's NFL Sunday Night Blockbuster
(NFL) 49ers (SF) vs. Bills (BUF),
Total: 44.50 | -108.00 Under
Result: Loss
If the weather forecast for this matchup holds true, it's going to make last Thursday's Steelers-Browns snow game seem like a warm day in Hawaii.

A winter storm watch with more than a half-foot of snow, 30 mph winds and a will chill factor near single digits is what is being predicted.

That's not good for Brock Purdy ... if he even plays after missing last week due to a sore right shoulder. 49ers backup QB Brandon Allen is a stiff, who isn't 100 percent either.

Aside from George Kittle, the 49ers' major weapons have been either disappointing or out for the season. Christian McCaffrey has done nothing since returning three games ago. He's averaged less than 50 yards rushing a game and has yet to score a touchdown. Pro Bowl left tackle Trent Williams remains out.

The Bills give up fewer than 20 points per game and could get back their best linebacker, Matt Milano.

The Bills have become far more run-oriented this season. That certainly should be the case for this matchup given the weather conditions and that Josh Allen again could be down two of his four best receivers. Dalton Kincaid has been ruled out and Keon Coleman is questionable.