The Eagles opened the season with a 32-6 win against Atlanta. Falcons QB Matt Ryan was held to 164 passing yards on 21-of-35 passing and no touchdown passes. The Niners are coming off a shootout win at Detroit, a game where the teams were a combined 5-for-5 in the red zone. I expect a much better defensive performance from San Francisco in this one.

Under is 5-0-1 in 49ers last 6 games after allowing more than 250 yards passing in their previous game. Under is 5-1-1 in 49ers last 7 games after allowing more than 30 points in their previous game. Under is 22-8 in Eagles' last 30 home games. Under is 12-4 in Eagles last 16 home games vs. a team with a winning road record.

10* play on UNDER.