The Niners are 1-2 on the season after taking a disappointing 10-11 loss at Denver last week. They are 5-1 ATS in their last 6 games following an ATS loss and they have owned the Rams in recent regular-season meetings, winning each of the last six.

The Niners have had this game circled since the schedule came out as they get a chance to avenge a loss to the Rams in last season's NFC Championship game. 49ers are 14-4 ATS in their last 18 Monday games.

10* PLAY ON SAN FRANCISCO 49ERS.