Missouri: The Tigers are at 2-2 (0-1 in the SEC), as they head to Baton Rogue to take on LSU on Saturday. Missouri can be an explosive team, as evidenced by the Tigers having have scored 140 points in their two victories. Missouri is fourth in the nation in passing yards per game (391.3), as sophomore QB Drew Lock has 14 TDs against just three interceptions (1508 yards, completing 59.3%). Missouri has the SEC's top offense (569.5 YPG), ranking fifth in the nation. The Tigers average 44.5 PPG (14th) and defensively are solid, allowing 18.8 PPG (29th) on 67.8 YPG (51st).

LSU: These Tigers (same nickname as Missouri) will take the field at 2-2 and without Les Miles on the sideline for the first time in nearly 12 years. LSU will be looking to recover from an 18-13 defeat against Auburn in which a final-play TD was overruled following replay, leading to the dismissal of Miles and the hiring of Ed Orgeron on an interim basis. "We're going to flip the script," said Orgeron, who was USC's interim coach in 2013, leading the Trojans to a 6-2 record. "We're going to do things different, we're going to do things that I've done in the past to re-energize this team." Junior RB Leonard Fournette leads the SEC with 128.7 rushing YPG (386 yards on 5.8 YPC) and has topped 100 in all three games he has played this season. However, it's been quite some time since LSU has featured an effective passing game and 2016 has been no different. Danny Etling has completed 56.3% for only 433 with three TDs and one INT.

The pick: Missouri joined the SEC in 2012 and finally gets to meet LSU, the only conference team that Missouri has not faced since joining the league. LSU has not lost an October game since 2009 and the change at the top ought to provide a spark dividends, at least in this first game. Lay the points and make LSU an 8* play.