The set-up: The Twins lost 2-0 yesterday and clearly they'll be eager to bounce back here after that listless effort. While Tuesday's contest stayed well "under" the posted number, I think that we're in line for more of a "slug-fest" on Wednesday afternoon. The visitors hand the ball to Jose Berrios, while the home side goes with Chase Anderson.

The pitchers: Berrios is so far 8-6 with a 3.52 ERA. Berrios most recently got blasted for six runs off six hits with four walks over 4.1 innings in a loss to the Cubs on Friday. And now Berrios has to pitch against another tough National League opponent in this inter-league contest. Note that while he's 6-2 with a 2.62 ERA at home, Berrios is just 2-4 with a 4.93 ERA on the road.

Anderson is so far 6-6 with a 4.18 ERA. Anderson most recently gave up one run off two hits with five strikeouts over six innings in a win over the Reds on Friday. Note though that it was just Anderson's second quality start since May. Also note that he sports a terrible 5.29 ERA at home this season.

The pick: Despite yesterday's result, note that Minnesota has still seen the total go "over" the number in 11 of 16 inter-league games this year. I'm banking on these starters getting the hook early and for this one to soar over, sooner rather than later.