The set-up: While he's looked decent in his limited time for the A's this year, I think Edwin Jackson takes a step back in this tough interleague matchup. Derek Rodriguez and the Giants will look to take advantage.

The pitchers: Rodriguez is so far 4-1 with a 2.89 ERA. The rookie has completely exceeded expectations and his peripherals suggest that his early numbers are sustainable. Rodriguez is so far 1-1 with a 3.79 ERA on the road and 2-0 with a 2.53 ERA in all "night" games.

Jackson is so far 1-1 with a 2.59 ERA. Jackson struggled in consecutive starts before the break after opening strong for his new team. It's hard to trust the veteran after consecutive years of complete ineptitude, as note that he was just 3-5 with a 6.40 ERA in all "home" games last year.

The pick: I think we can throw stats out the window here. I'm basing this particular play on the starting pitchers. Rodriguez enters on top form, while Jackson looks poised for a major letdown against this tough Giants' line-up. Play on San Francsico.