The set-up: The massive talent gap on the mound in this matchup makes the Diamondbacks on the "run-line" the correct call in this one in my opinion. The visitors hand the ball to ace Zack Greinke, while the home side goes with Luis Perdomo.

The pitchers: Greinke is so far 11-5 with a 3.05 ERA. Greinke most recently gave up one run off two hits over eight innings while striking out 13 and walking one in a win over Colorado on Sunday. Note that it was the sixth straight start in which he's allowed two or fewer runs.

Perdomo is so far 1-5 with a 6.99 ERA. He most recently allowed three runs off five hits over six innings in a loss to Philadelphia on Sunday. Perdomo is so far 0-4 with an 11.29 ERA at home this year.

The pick: Perdomo has shown nothing whatsoever to suggest that he's going to suddenly "flip a switch" and regain his form. In fact, the right-hander will likely be moved back to the bullpen shortly when others become healthy. Greinke on the other hand has gotten progressively better as the season has worn on and I look for that trend to carry over here with another dominant performance. Play on the Diamondbacks on the "run line."