The set-up: Indianapolis comes in off a 21-9 road win over Washington and I think it'll be able to keep this one competitive as well against an Eagles team which comes in off a 27-21 loss to Tampa Bay.

The teams: Colts' QB Andrew Luck had 179 passing yards, two TD's and two INT's last week. TY Hilton had seven catches for 83 yards. So far the Colts are averaging 22 PPG, while allowing 21.5. Last week the defense was especially sharp in not allowing a TD.

The Eagles are averaging 19.5 PPG and they're also allowing 19.5. QB Carson Wentz makes his debut (finally), but clearly the pivot is going to have to go through some "growing pains" before obtaining his previous form. Philadelphia looked horrible against the pass last week, giving up 402 yards to Ryan Fitzpatrick.

The pick: Take it for what you will as well, but Indianapolis is 6-3 ATS in its last nine non-conference games, while Philadelphia is just 2-3 ATS in its last five as a favorite in the 3.5 to 9.5 points range. I think Luck keeps this one close. Grab the points.