The set-up: The 49ers are 1-4 and last place in the NFC West. This is a "must win" game for San Francisco if it hopes to compete in the playoffs. Starting QB Jimmy Garraopolo was lost to injury for the season three weeks ago, so it's "do or die" tonight. The 2-2-1 Packers have looked brilliant at times this year and very pedestrian in others. Hall of Fame QB Aaron Rodgers will be eager to bounce back in front of the home town crowd.

The teams: San Fran is now led offensively by RB Matt Breida, who is averaging 7.5 yards on 49 carries so far this year. QB CJ Beathard makes his third start after falling 29-27 to the Chargers most recently.

Rodgers comes in sporting an elite 10:1 TD/INT and I have a hard time seeing San Francisco slowing him down tonight after the critics have been quick to jump on him after last week's sub-par effort.

The pick: Take it for what you will as well, but Green Bay has seen the total go "over" the number in 15 of its last 25 home games as a favorite of 9 points or more. I'm expecting a wide-open affair, play the "over."