The set-up: The Angels have won six straight, but I think they'll stumble in the opener of this difficult road trip and in the National League setting. LA also leaves the coast without slugger Mike Trout in the line-up, who was recently injured. The under-achieving and hungry Cubs will look to take advantage. Also note that it's unseasonably cold in Chicago right now, which will clearly effect the team from California.

The pitchers: The Angels hand the ball to Tyler Skaggs (1-1, 2.45 ERA) who gave up one run off five hits over 6.1 innings in a win over the Rangers on Saturday.

The home side counters with Cole Hamels (1-0, 5.73) who gave up two runs off six hits over six innings while striking out five in a 14-8 win over the Brewers on Saturday.

The pick: Take it for what you will as well, but LA is just 1-5 (-4.2 units) on the road this year, while Chicago is 26-17 the L2 years in all interleague contests. I'm laying the price.

Chicago Cubs

10* play