The set-up: Dallas hasn't put a lot of stock into the preseason (0-6 in its last six Week 1 contests). That includes a 24-21 loss to San Francisco in Week of the preseason last year. The 49ers turn to backup QB's Nick Mullens and CJ Beathard, who will be in a fight for the No. 2 spot with Jimmy Garoppolo returning shortly. Mullens comes in with plenty of confidence after leading the way for the 49ers last year with 2,277 passing yards and a 90.8 passer rating. The Cowboys won't have Dak Prescott or Ezekiel Elliot on the field of play today. Cooper Rush and Mike White will be splitting time under center for the visitors.

The pick: As mentioned above, Jason Garrett simply doesn't put much emphasis on the preseason as evidenced by the Cowboys winless 2018 preseason, scoring 13 points or fewer in three of the four games (note that San Fran has NEVER scored fewer than 13 points in eight preseason games under its head coach Shanahan.) This one has "blowout" written all over it; play on the home side money line.

San Francisco 49ers 10* play