The set-up: No need to overthink this one. Indianapolis has a lot of talent, but the Colts will clearly be looking for an identity moving forward after QB Andrew Luck shockingly announced his retirement from football just a couple of weeks ago. Jacoby Brissett is a capable QB, but the mental blow that Luck's departure will have on this organization will clearly take some time to get over.

The pick: Yes the Chargers are without RB Melvin Gordon, but I've always been of the thought that RB's are replaceable in the NFL. The experience that Chargers' QB Philip Rivers brings to the table is the difference maker here. Brissett only threw 15 passes in the preseason and he sat out the third and fourth games. Rest leads to rust for Brissett and the rudder-less Colts. Lay the money-line on the home side here.

LA Chargers Moneyline 10* play