The set-up: Both teams come in off tougher than expected victories. That said, I was more impressed with Drew Brees and the Saints in Week 1. While I clearly wouldn't be shocked by an outright upset, in the end I'll recommend grabbing up the points. Remember, this is a "revenge" game for New Orleans, which was knocked out of the playoffs last year by the Rams on a controversial call. I think the Saints got looking past the Texans last weekend. That said, clearly Houston looked a lot better than LA's opponent Carolina did.

The pick: Last week Rams' star RB Todd Gurley had 97 yards on 14 carries, but the health of his knee is still in question. And despite HOW the Saints won last weekend, they're still the ONLY team in the NFC South which emerged victorious after Week 1. The stage is now set for Brees to get his revenge vs. the undermanned/injured Rams. I think the conditions are right for a minor upset in this one.

1* FREE PLAY on New Orleans Saints.