As dominant as the Rams were in game one vs the Seahawks, their chances of upsetting the 49ers are slim. Stafford had a field day vs Seattle but was very well protected (0 sacks). It is highly unlikely that Stafford will have near as much time to operate on Sunday. The Rams again don't appear to be focusing on the run again this year, and even if they did, SF is very tough on the ground. The 49ers had 5 sacks last week, and Stafford is not the most mobile of passers. Purdy, on the other hand, saw a lot of TJ Watt last week, was sacked 3 times, but he still finished with a very solid game, ending with a 111 passer rating. Purdy has, as we know, great targets,and he put to rest some of the concerns about his success this year. The 49ers ran for 144 yards with McCaffrey leading the way. He has been a huge thorn in the side of the Rams in past meetings. The lack of a Rams run game, and the toughness and skill of the 49ers as a complete entity will be more than the Rams can handle. Look for SF to give Purdy better protection, and take SF to win and cover.