The Seahawks beat the 49ers in early October, but much has changed since then. The 49er have what the Seahawks need, which is a running game. Seattle has averaged only 65 yards in their last three starts. Wilson is exposed, and the Seahawks’ possession time is limited. The resurgence of the 49ers’ running game coincides with the recent strong performance of Garoppolo. The 49ers, 6th rated and rising in rushing yards are averaging more than double the yards per game. Missing Samuel will be a loss on the ground and in the air, but Mitchell ran for 130+ yards on his own last week.

Wilson looked better last week but the WFT’s pass defense isn’t even on the same planet as the 49ers’. It will likely be a long game for Wilson; the Seahawks’ offensive line is allowing more than 3 sacks a game, and the 49ers’ defense take no prisoners.

Garoppolo has been effective and efficient, with very impressive stats in his last few games. He has only thrown two interceptions in 5 games, and has had good protection. The Seattle passing defense is rock bottom in yards allowed, and does not pressure well. With a strong running game, and a good offensive line, look for Garoppolo to have something of a field day. Final nail in the coffin: Seattle has been miserable at home, while the 49ers are road warriors this year and are 4-1 ATS lately.

Favorable odds are out there. Take the 49ers to win and cover.