The Giants are home to the Colts in Week 17. It is a very significant game for NY, and they likely couldn't have a better opponent. The Colts are going nowhere fast, with an indifferent game last week and essentially no offense. Foles, with very limited time with the team, was about as expected; 3 points and a trio of picks. On a short week for the Colts, don't expect huge improvements from him.
The Colts' usually dependable defense has fallen apart in the last three games; their avg. points-allowed has ballooned to 37, they bombed against the Cowboys and were humiliated in the second half by the Vikings. They are still tough on passers with 4 sacks last week, but their run defense is not elite, allowing 137 yards and 2+ TDs on average L3 games.
The Giants have the edge in all offensive categories. They can run or pass, with both Barkley and Jones playing well lately. Jones' passer rating is consistently in the 90's. He has cut down on turnovers, and can gain ground with his legs too. He put up over 350 yards last week, but won't manage that against the Colts.
The Colts are, in my opinion, done for the year. They had 69 yards on the ground and 104 in the air last week against an average Chargers defense. The Giants' postseason is ripe for the picking. They are healthier and at home. Take the Giants to win and cover.