San Diego at Chicago Cubs 8:05 ET
Cubs over Padres- Chicago has dropped eight straight games while the Padres have won their last five and yet here are the Cubs favored. The Padres have never started better, as they are also 22-11 on the road but are just 2-5 in their last seven trips to Wrigley Field and 3-8 in the last 11 meetings overall. The Cubs will give touted prospect Caleb Kilian (0-0 5.40 ERA) a second major league start in this contest. The Padres are expected to call up Ryan Weathers from Triple-A El Paso to make his 2022 debut. The left-hander pitched in 30 games (18 starts) for San Diego last season, when he made his big-league debut, and went 4-7 with a 5.32 ERA. Weathers, 3-4 with a 7.29 ERA in 12 minor league starts this season, allowed seven runs and 12 hits over 10 innings while going 1-1 in two starts against the Cubs in 2021. Take CHICAGO CUBS.