Harvard can shoot and doesn't turn the ball over.
Harvard is not your typical Ivy league team they have wont he league for a 4th year in a row and they have a balanced offense with a very good defense ranked 33rd in adjusted rankings. Cinci has a very poor offense and the American Conference really was not that strong.
Harvard has a few guys who can stick it from deep with Laurent Rivard and Siyani Chambers. Cincinnati coming in off a loss where they have been playing off their game as of late.

The Crimson enjoyed another strong season and will be representing the Ivy League again. The preseason hype of this being a top 25 type team died down pretty quickly but they are still going to be a very tough out.
Last year they knocked out New Mexico in the round of 64 and a lot of the same players are back and looking to go further this season. They are not a team to be easily dismissed.
Harvard runs a deliberate offense and they are efficient with it. They have a very good group of outside shooters which can keep them in most games led by Siyani Chambers and Laurent Rivard who both make 40% or more of their shots from behind the arc.
They have 5 players that average 10 or more points which will make it hard for Cincinnati to focus on shutting down leading scorer Wesley Saunders.
The spread tells you a lot in this one and I really like Harvard to pull the upset.