The Chiefs rarely lose two in a row. It happened once last year and the year before, and in other recent seasons, not at all. They lost last time out at home against one of the best teams in the league, the Buffalo Bills, and it was close to the end. The 49ers have an elite defense and allow 14.8 PPG, but they have a slew of injuries on that side of the ball. Even though some of the injured players might go, like Nick Bosa, they will not be 100%. They also might be without their starting left tackle. The Chiefs score about 30 PPG, and the 49ers just 20. The Niners D will be too compromised to stop the Chiefs, and they - even with the addition of Run CMC from the Panthers won't be able to keep up. Chiefs minus 1.