The San Francisco 49ers have a division matchup with the Arizona Cardinals. San Francisco comes into this game at 10-3 while Arizona is currently 3-10. San Francisco has won five in a row. The Cardinals were in the running for the top draft pick but for some reason, they have decided to win two of their last four games. San Fran has been blowing teams out over their winning streak, with an average margin in their wins being 19.4 points. They have the league’s third-best offense with 29.2 points a game. They will be facing a Cardinals defense that ranks 30th with 25.5 points allowed per game. San Francisco is 4-2 ATS in their last six matchups against the Cardinals. San Fran is in a fight for the top spot in the NFC and even though they are in the driver's seat they can’t let up on the gas.

Play on San Fran. This is a 3% play.