You have to go with the better coached team in this scenario. Even though Russell has historical knowledge on how the 49ers play football, the HC Nathaniel Hackett hasn't done the best job to start his coaching campaign. Kyle Shanahan will be able to exploit the inferior offensive line of the Broncos who have allowed 5 sacks in 2 games (3 vs the texans) so with San Fran fully healthy on the defensive side, it will be tough for a QB in a new system vs a team who has been rocking together for 2+ years now. Chemistry and team longevity will win the game for SanFran who will be a better team with the return of George Kittle and Jeff Wilson Jr Back, AND Jimmy Garapolo under center.

Official Play : 49ers -1 (or -1.5)

Side Bet: Deebo Samuel Over 32.5 Rushing Yards