The San Francisco 49ers (-2.0) are the favorite vs. the Kansas City Chiefs (+2.0). There are 64 games in our database similar to this matchup. Of the 64 games, the Advanced Sports AI model was correct 53% of the time. Our prediction is that Kansas City is more likely to cover the spread than San Francisco based on matchup characteristics and historical analysis. PICK: Kansas City +2.0 points or more. However, for a line of SF -2.5 (FanDuel), the prediction improves to 58% (out of 71 similar games) for Kansas City +2.5 to cover.