There were 64 points scored in Carolina's 34-30 opening week loss to the Raiders. Those kinds of Overs are going to be typical in Panthers games this season. Carolina has the worst defense in the league and an up-tempo offense with the top all-purpose back in the NFL, Christian McCaffrey. That combination is going to produce a lot of Overs. 
Tom Brady and his left tackle Donovan Smith didn't play well opening week against the Saints on the road. Now the Buccaneers drop well down in class. Those two are in good position to atone for their poor performances. 
Brady and his bevy of high-caliber receivers should light up an inexperienced Panthers defense that allowed game-manager type Derek Carr to have an 8.0 YPA and failed to record not only  a sack, but failed to even get a quarterback hit. The Raiders hadn't scored that many points in their last 29 games. Brady is most comfortable in the pocket. He shouldn't be bothered. Brady with time still is a high level quarterback. 
Carolina should contribute to this total going Over, too. The Panthers have an aggressive spread-the-ball around passing approach and a new deep threat, Robby Anderson. McCaffrey is a major plus because defenses key on him rather than quarterback Teddy Bridgewater.