The Arizona Wildcats have won their first two games of the tournament by a combined 36 points, and they are a double-digit favorite in their Sweet 16 match-up versus Xavier. The Musketeers had a pretty easy path to the Sweet 16, with a win over Ole Miss in their first game, and then a lucky draw against minnows Georgia State. I think the luck runs out for the Musketeers tonight.

Here are my keys to the game:

1. Previous History - The Wildcats were ranked among the Top 10 all year, and Xavier only faced one team that was ranked in the same neighborhood as Arizona. They faced Villanova three times, losing all three games by double-digits. The Musketeers have also failed to cover in four of their last five versus teams from the Pac-12.

2. Arizona Defense - The Wildcats have allowed an average of just 59 points per game this season, 8.3 points fewer than Xavier. They held Ohio State to 58 points on 38.5% shooting on Saturday.

3. X-Factor - Arizona comes into this game on a 13 game win streak, and 11 of those 13 victories came by a margin of double-digits.

Selection: This is a play on the Arizona Wildcats (10*)