Seattle Seahawks -6.5 (10*)
(NFL) Seattle vs. San Francisco,
Point Spread: -6.50 | -110.00 Seattle (Away)
Result: Win
The Seattle Seahawks blew another late lead at home to Carolina on Sunday, but you have to like their chances of bouncing back on Thursday night in San Francisco. The 49ers defeated a pretty poor Baltimore team on Sunday, but the win wasn't overly impressive. Colin Kaepernick hasn't performed well against top tier defenses, and this Seattle team is still dominant on the defensive side of the ball.

Here are my keys to the game:

1. Previous History - The Seahawks swept the season series last year, and they are 6-0-1 ATS in the last seven meetings versus San Francisco. Kaepernick has thrown three TDs and nine INTs while going 1-5 in six starts versus Seattle.

2. Carlos Hyde - San Francisco's running back ran for 168 yards and two TDs in a Week 1 win over Minnesota, but hasn't reached 100 yards since. He's unlikely to be very effective running against this Seattle defense that remains one of the best in the NFL.

3. X-Factor - The Niners are allowing a league worst 306 passing yards per game, and Joe Flacco torched them for 343 yards and two TDs last week.

Selection: This is a play on the Seattle Seahawks (10*)