The Buffalo Bills opened the season with an emphatic home win over the Colts, and they have alternated wins and losses ever since. Coming off a loss to the Bengals last week, I expect that trend to continue against a the lowly Jacksonville Jaguars here this Sunday. This game is being played across the pond in London, so not the early start time.

Here are my keys to the game:

1. E.J. Manuel - The Bills will turn to Manuel again this week as Tryod Taylor is still battling a knee injury. He threw for 263 yards with a TD and an INT in the loss to Cincinnati this week, but we should expect him to be a little sharper in his second start of the season. Manuel threw for 193 yards with a pair of TDs and one INT in a 27-20 win at Jacksonville in 2013, his only previous start versus the Jaguars.

2. Jaguars Running Game - Jacksonville isn't scaring anybody with it's ground game, averaging just 92.7 yards per game, ranking 21st in the league. Even more concerning is their grand total of ZERO rushing touchdowns in 2015.

3. X-Factor - LeSean McCoy sure looked healthy last week, running for 90 yards and a TD on just 17 carries.

Selection: This is a play on the Buffalo Bills (8*)