The Cubs handed the Giants a lopsided loss in the series opener in San Francisco last night, and I think we could see another slugfest here in Game 2 Saturday. Chicago ranks third in the major leagues in runs scored, and those big bats should be able to take advantage of a struggling San Francisco starter.

Here are my keys to the game:

1. Pitching - Matt Cain will get the call for the Giants, and he's coming off a solid outing. Cain (0-5, 5.87 ERA) allowed one run on seven hits over seven innings in a no decision at Arizona in his last outing. He's 0-3 with a 5.40 ERA at home this season, and he's 0-2 with a 5.48 ERA in his last four starts against the Cubs.

2. Batter vs. Pitcher - The over is 11-4-2 in Matt Cain's last 17 starts, and the Giants have lost his last four starts versus Chicago.

3. X-Factor - These teams have gone over in seven of the last 10 meetings, and the over is 8-3-1 in the Cubs last 12 road games.

Selection: This is a play on the Cubs@Giants to go OVER the total (10*)