The set-up: The White Sox opened their 10-game road trip with four straight losses, including the first of a four-game series in Seattle on Thursday. However, Chicago took the final three games of its series in Seattle, capping the successful weekend with Sunday's 8-1 win. Chicago allowed a total of three runs from Friday through Sunday and open a three-game interleague series tonight in Arizona against the Diamondbacks. Arizona won Friday and Saturday at San Diego (scored a total of 19 runs) but saw its five-game winning streak snapped with Sunday's 5-1 loss.

The pitching matchup: Miguel Gonzalez (3-4 & 4.29 ERA) will start for Chicago and Zack Greinke (5-2 & 3.09 ERA) for Arizona. Gonzalez lost his fourth consecutive start this past Wednesday in Anaheim against the Angels. He allowed five runs on six hits and issued a season-high five walks over 5 2/3 innings. He has now surrendered five or more runs three times during his skid, while registering more than two strikeouts just once. Gonzalez settled for a no-decision in his only career outing against Arizona in 2013 while with Baltimore, despite allowing only two runs over seven Innings (2.57 ERA but his team lost). Greinke was not sharp against the New York Mets on Tuesday but came away with his fourth straight win, despite giving up four runs on five hits in 6 2/3 innings. It marked only the third time nine starts this season that he has allowed more than three runs. However, Grienke has not pitched well against Chicago during his career, going 7-10 with a 4.14 ERA in 23 starts (team is 10-13) and three relief appearances.

The pick: Gonzalez has given up 34 hits and 19 runs (18 earned) in his past four starts covering 23 1/3 innings (6.94 ERA). He is 1-3 with a 4.88 ERA in five road starts in 2017 (team is 2-3) with a 1.60 WHIP. In contrast, Greinke is 4-0 in six home starts (team is 5-1), posting a 2.82 ERA and 0.71 WHIP. Make Arizona an 8* play.