The set-up: The Minnesota Vikings had 'tongues wagging' by opening teh 2016 season 5-0 SU & ATS. However, after a Week 6 bye, the Vikings lost their mojo, losing four in a row SU & ATS. The team never recovered, losing eight of its final 11 games to finish teh season 8-8 (9-7 ATS). Minnesota is out to prove its hot start wasn't a fluke and that the Vikings can challenge the Packers for the division title (we'll see). The Bills gave up on Rex Ryan and would finish 7-9, extending to 17 seasons, the NFL's longest playoff drought. The Bills have employed nine different head coaches during their playoff drought and I wish Sean McDermott "the best of luck," as he's been named the 20th head coach in team history.

Minnesota: It's a new era in Minnesota, as Adrian Peterson is no longer roaming the backfield. The Vikings will feature Jerick McKinnon, rookie Dalvin Cook, Bishop Sankey and Terrell Newby running behind fullback C.J. Ham. QB Sam Bradford completed 71.6 percent of his passes last season with 20 TDs and just five INTs but rarely threw downfield. That has to change.

Buffalo: Tyrod Taylor is entering his third season as Buffalo's starting QB and he has passed for more than 3,000 yards in each of the past two years and has 37 TD passes against just 12 interceptions during that span, yet most feel he isn't truly Buffalo's answer at the position. Buffalo was a force on the ground last season as LeSean McCoy had a bounce back season (1,267 yards / 5.4 YPC / 13 TDs) behind an excellent OL. However, the he oft-injured Sammy Watkins remains a big question mark at WR.

The pick: Word is that he Vikings are doing the best they can to avoid preseason injuries but one can't ignore that they have played to win these relatively meaningless contests. Minnesota went undefeated in the preseason in 2016 and is 12-1 SU in its last 13 preseason outings dating back to 2013. Make the Vikings an 8* play.