The set-up: Clemson head coach Dabo Swinney claims he loves playing in big games and his team's showdown against Louisville on Saturday night certainly qualifies. ABC will be on hand as current AP No. 3 Clemson (2-0) and the defending national champs, travel to Papa John's Cardinal Stadium in Louisville, Ky. to take on 2-0 Louisville, which is currently ranked 14th in the AP poll. Eventual Heisman Trophy winner Lamar Jackson almost single-handedly lifted Louisville to victory in last year's contest at Clemson, totaling 457 yards and accounting for four TDs in a game that wasn't decided until Louisville came up one yard shy of a first down at the Clemson 3-yard line in the final seconds (Clemson won 42-36). Clemson has won all three previous meetings between the two schools, although each has been decided by six points or less.

Clemson: New Tiger QB Kelly Bryant has passed early tests (68.6% completions with one TD & one INT plus 136 yards rushing on 5.2 YPC with three TDs). However, after routing Kent State 56-3 (665 total yards), the Tigers gained just 281 yards in their 14-6 win over Auburn. So far, the key has been Clemson's defense. The Tigers' defensive front, anchored by All-America candidates Christian Wilkins and Dexter Lawrence at tackle, plus Austin Bryant and Clelin Ferrell at end, may be the best in the country. Clemson had 11 sacks, one shy of the school record against Auburn last Saturday. The Tigers rank second nationally in total defense (118.5 YPG) and sacks and are in the top-10 in seven defensive categories. Clemson has not allowed a TD this season and held Auburn to 117 total yards (13 FDs), including 15 second-half yards! Amazingly, Clemson's allowing 4.5 PPG but that ranks just THIRD (?).

Louisville: Jackson's performance last season in "Death Valley" set up his "Heisman-push" (295 YP / 162 YR / 3 total TDs). Only Archie Griffin has won two Heismans (back-to-back in 1974 and 1975) but Jackson is not about to relinquish his Heisman without a fight after 525 yards of total offense at North Carolina. He enters this game with 771 passing yards and a 5-0 ratio plus 239 rushing yards with three TDs after just two games. Jackson has became only the second player in FBS history to have at least 300 yards passing and 100 yards rushing in consecutive games.

The pick: Clemson has won 10 consecutive games on opponents' home fields but Louisville is still smarting from last year's loss in Death Valley. There is no doubt that Clemson's defense is special but it couldn't contain Jackson at home last year (see above). How can it do better here at Papa John's Cardinal Stadium in Louisville? "We've had three really good battles with them – had our opportunities and have come up short – so this is something that is really important to our players," Louisville head coach Bobby Petrino told reporters. "First of all, we should have confidence that we're there and that we can play, but it is up to us to win the game."I agree and will make Louisville my 10* CFB Game of the Year!