The set-up: No. 17 Louisville has opened 4-0 and will travel to West Lafayette for Tuesday's ACC/Big Ten Challenge to face the 5-2 Purdue Boilermakers at Mackey Arena. The Cardinals really haven't been tested yet, opening the season with wins over George Mason, Omaha, Southern Illinois and St. Francis (Pa.). However, in Friday's win over St. Francis, when junior Ray Spalding left in the second half with an ankle injury, a 22-point lead was whittled to eight in the 84-72 triumph. Purdue rolled to victories in its first four games by a combined 157 points while averaging 102 points but lost 78-75 (OT) to Tennessee 78-75 in the opening round of the Battle 4 Atlantis. The Boilermakers then got upset 77-73 by Western Kentucky in the next round. However, Purdue recovered nicely against Arizona, shooting 57 percent and draining 11-of-22 shots beyond the arc in the 89-64 victory.

Louisville: The Cardinals have had NCAA-related problems this fall, including the FBI investigation into bribery and corruption in college basketball, a mess that cost veteran coach Rick Pitino his job, replaced by former Cardinal player David Padgett on an interim basis. The 6-10 Spalding (12.0 & 9.3) matched his career high with 19 points on 8-of-10 shooting and set a new personal best with 13 rebounds and five blocks in just 26 minutes against the Red Flash before getting hurt (he is questionable for Purdue). This will be Louisville's first road contest and interim coach David Padgett told reporters, "It's going to be an eye-opening experience for the young guys just because they've never done it before, "It's going to be welcome to the jungle a little bit because there are not many places in college basketball that are tougher to play in than Purdue." Senior guard Quentin Snider (8.3 & 4.0 APG) and 7-0 senior Anas Mahmoud (7.5 & 7.8) plus 6-7 junior Deng Adel (team-high 17.5 points plus 5.5 RPG ) will be counted on heavily, especially if Spaulding can't go.

Purdue: The win over then No.2 Arizona was Purdue's second-largest margin of victory against a ranked foe in school history. "It's good that they were resilient and they bounced back and they won a game," Purdue coach Matt Painter said. "But I don't think it answers what happened in the other two games. The other two games, we didn't make shots. You have to be able to win versus good people when the ball doesn't go in." Also of note is that the Purdue beat an Arizona team which went 0-3 in the Bahamas, becoming the first team ranked No. 2 to fall out of the top-25 in one week's time since the the 1986-87 season (ironically, that team was Louisville!). The Boilermakers return four starters from their 2016 Big Ten championship team, making them as experienced as any team in the country. Sure, Caleb Swanigan (18.5 & 12.5) is a huge loss but 6-8 senior forward Vince Edwards (12.6 & 4.9 LY) is the only active player in the nation with at least 1,000 pints, 500 rebounds and 300 assists. Guards Edwards (18.0 & 4.4) and Mathias (16.1-4.7-4.7) lead in scoring from the perimeter with Edwards (14.0 & 9.0) and the 7-2 Haas (14.4 & 5.3) taking care of business inside. Then there is the 7-3 Matt Harms (6.3 & 4.1), who has blocked 21 shots in just 125 minutes this season.

The pick: Purdue leads the all-time series 11-6 but Louisville won last year's matchup 71-64 at home, ending Purdue's seven-game winning streak in the ACC-Big Ten Challenge. Will Purdue start another winning streak here? I think not, as the Boilermakers have done quite a bit of traveling and this Louisville team is rested plus is playing with a chip on its shoulder from all the "off-the-court" issues. Make Louisville a 10* play.