The set-up: Both teams are hungry here after Week 1 setbacks. Both clubs looked horrible defensively last weekend and I think that'll be the case here again as well. This number is a little low.

The teams: The Bills lost 47-3 last week. Josh Allen has been named the starting QB in Week 2 after Nathan Peterman imploded. LeSean McCoy only had 22 yards last week, after finishing with over 1,100 last year. Clearly the only way the Buffalo offense can go is up. The defense gave up 369 yards, including allowing Baltimore to go 6 for 6 in the Red Zone.

LA QB Philip Rivers will be looking to exploit the Bills' weak pass defense. The Chargers were decent defensively last year, but the unit struggled in Week 1 and I think it'll have its hands full here against a Buffalo offense that's out to atone itself.

The pick: Take it for what you will as well, but LA has seen the total go "over" in four of its last six as a favorite in the 3.5 to 9.5 points range, while Buffalo has seen the total go "over" in 12 of its last 15 at home. With each side pushing the pace and hungry for a win, I look for this total to fly "over" sooner, rather than later.