The set-up: Here's another one where I don't think that the home floor advantage can be overlooked as a very real deciding factor. The Cardinals look poised for a letdown after their very satisfying 72-64 road win over Virginia Tech. The Seminoles return him off a road victory over Syracuse. FSU won't be taking anything for granted here after Louisville took two of three in the season series last year. The Cards average 78.8 PPG and they allow 68. The Seminoles though are 10-1 on their home floor and they average 77 points and allow 68.3.

The pick: Take it for what you will as well, but Louisville is just 4-7 ATS in its last 11 off a road win vs. a conference rival, while FSU is 3-1 ATS in its last four off an upset win over a conference rival as an underdog. Lay the points, expect a rout.

10* play