The set-up: I got down early and have a favorable line in this one, but regardless, I like San Francisco to come in focussed on the task at hand and to once again run up the score quickly in this one as it then gets ready to play Seattle the following week. Clearly this is a big game for Arizona, as it sits at 3-4 and another loss will essentially take it out of the running for a playoff spot with both Seattle and San Francisco in its division. But San Francisco's depth on the defensive side of the ball and it's strong run game is going to prove to be too much for Cards' rookie QB Kyler Murray today.

The pick: Arizona enters off a tough road loss to the Saints and I don't think the home side has gotten over that setback. It's interesting to note as well that San Fran is 2-0 ATS in its last two Thursday night contests, while Arizona is interestingly 0-3 ATS in its last three following a two game road trip. No upsets this week, lay the points.

10* GAME OF THE WEEK on the San Francisco 49ers.