The set-up: The Colts are ripe for the picking here in my opinion after their loss to Miami last week. Indy hopes to have QB Jacoby Brissett under center, but I think the uncertainty surrounding this is definitely not doing the home side any favors today. The Jags on the other hand finally welcome back Nick Foles under center and I think the Super Bowl MVP is going to be the difference here. Also note that the Jags are fresh off their bye week. From a situational stand point, there's no question this one sets up great for the outright upset.

The pick: Additionally note that Jacksonville is already 3-1 ATS on the road this season and 7-3 ATS in its last ten off an upset loss as a favorite, while Indy is just 3-3 ATS at home and only 7-11 ATS in its last 18 after playing a game at home. The outright is possible, but in the end let's grab the points.

8* play on the Jags.