The set-up: The 49ers beat the Cards 28-25 back on November 1st, and then lost 27-24 to the Seahawks last weekend. San Francisco's perfect season is now firmly in the rear view mirror and clearly teams are finding ways to score on it. Arizona comes in off a 30-27 setback and Tampa Bay and while its playoff hopes are slim, clearly the team isn't throwing in the towel on the season.

The pick: Note as well that the Cards have lost three games by six or fewer points and in their season opener against Detroit they tied. If a few plays went the other way, Arizona could have many more wins under its belt right now. Note as well that San Fran is a poor 1-5 ATS in its last six vs. teams with losing records, while the Cards are 5-1 ATS their last six on the road. I think the outright win is possible as well here. That said, in what I expect to be another highly competitive affair, let's grab the points.

8* play on the Cardinals.