The set-up: The Colts come in off a win over the Jaguars, but I think they'll struggle here vs. a Houston team which enters off a loss to the Ravens. While Indianapolis will have Jacoby Brissett under center, note that it'll be without the services of top RB Marlon Mack, who suffered a broken hand. This is a major hit to an offense which relies on a strong run game to open things up for Brissett.

The pick: The Texans not only want to bounce back after last week's loss to the surging Ravens, but they also play with revenge here after losing to the Colts by 7 in Indianapolis earlier in the year. Houston has had plenty of difficulties over the years with the Colts and while the struggled last week, I think this one sets up well for a bounce back performance. The short week favors the home side and I'll point out that Indy is in fact just 12-15 ATS in its last 27 as an underdog and 0-2 ATS in its last two "Thursday night" games, while Houston is 5-1 ATS in its last six in revenging a road loss vs. an opponent and 2-0 ATS in its last two Thursday night games. Lay the points.

10* GAME OF THE WEEK on the Texans.